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Greater Reductions in Exacerbations Remains an Open Area of Opportunity in the Chronic Obstructive Pulmonary Disease Market

Companies mentioned in this article: Decision Resources Group

BURLINGTON, Mass., April 24, 2014 /PRNewswire/ -- Decision Resources Group finds that surveyed U.S. and European pulmonologists agree that a therapy offering a greater reduction in exacerbations is among the areas of greatest opportunity for chronic obstructive pulmonary disease (COPD) treatments. The majority of surveyed U.S. payers also indicated that improved ability on this end point would be worthy of a premium price relative to Boehringer Ingelheim/Pfizer's Spiriva. Although clinical data and the opinions of interviewed thought leaders indicate that, to date, no emerging bronchodilators have demonstrated the potential to fulfill this unmet need, pulmonologists will also look for improvements in lung function and quality of life, which many of the novel COPD therapies will offer.

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Other key findings from the DecisionBase 2014 report entitled Chronic Obstructive Pulmonary Disease: Amid the Emergence of a Novel Class of Dual Bronchodilators, What Are the Key Areas of Opportunity for Differentiation According to Pulmonologists and Payers?:

    --  Clinical data and the opinions of interviewed thought leaders indicate
        that the emerging LABA/LAMA fixed-dose combination class is highly
        anticipated, with Novartis's Ultibro poised to stand out from current
        therapies on measures of both lung function and quality of life.
    --  Surveyed pulmonologists indicate that a lower incidence of respiratory
        infections is a key area of unmet need among safety and tolerability
        attributes. Along with significant cardiovascular side effects,
        respiratory infections also weigh heavily in treatment decisions for
        both U.S. and European pulmonologists. Thus, a novel treatment that has
        a lower incidence of respiratory infections could secure physician
        preference upon entering the COPD market.
    --  A greater ease of administration is the delivery attribute with the
        greatest opportunity for differentiation within this increasingly
        competitive market. Pulmonologists ascribe a moderate level of unmet
        need for therapies with a greater ease of administration, and half of
        U.S. MCO pharmacy directors would be willing to include a once-daily
        LABA/LAMA priced at a premium to Spiriva on their formulary, based
        solely on its more convenient delivery.

Comments from Decision Resources Group Analyst Colleen E. Albacker, Ph.D.:

    --  "Our analysis of physician survey results reveals that price per day is
        the strongest factor when physicians are considering novel treatments.
        This finding is critical to new agents in this market that offer only
        incremental improvements in efficacy, safety, and delivery--a fixed-dose
        combination of two more-expensive therapies will have to keep its price
        in check to secure optimum uptake."
    --  "Based on thought-leader opinion and clinical data, our drug comparator
        model demonstrates that all of the emerging therapies for COPD have
        efficacy, safety, or delivery advantages over current sales leaders.
        This will lead to a very competitive and crowded market over the next
        few years, and developers of novel agents will need to take steps to
        emphasize advantages their agents possess over existing therapies to
        capture significant market share."

About Decision Resources Group

Decision Resources Group offers best-in-class, high-value information and insights on critical issues within the healthcare industry. Clients rely on this analysis and data to make informed decisions. Find out more at www.DecisionResourcesGroup.com.

All company, brand, or product names contained in this document may be trademarks or registered trademarks of their respective holders.

For more information, contact:

Decision Resources Group
Christopher Comfort
781-993-2597
ccomfort@dresourcesgroup.com

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SOURCE Decision Resources Group