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Rising Antibiotic Resistance Rates in European Hospitals Continue to Drive Shifts in Treatment of Gram-Negative Infections

Companies mentioned in this article: Decision Resources Group

BURLINGTON, Mass., May 15, 2014 /PRNewswire/ -- Decision Resources Group finds that the majority of surveyed hospital-based infectious disease and critical/intensive care specialists in the EU5 (France, Germany, Italy, Spain and the United Kingdom) reported increases in infection rates due to key drug-resistant Gram-negative pathogens (GNPs) over the past two years. Further, insights from physicians indicate that concerns over drug resistance are driving changes in treatment practices. Although piperacillin-tazobactam remains the preferred choice for empiric treatment for most Gram-negative infections (GNIs), a high percentage of respondents prefer using carbapenems in empiric therapy, suggesting that these agents, typically reserved for later-line use, are increasingly being prescribed as frontline therapies. Surveyed physicians also reported a significantly lower empiric treatment success rates in GNIs compared with our 2012 study, possibly driven by increasing GNP antibiotic resistance rates.

Other key findings from the TreatmentTrends report entitled Gram-Negative Infections 2014 (EU):

    --  Physician concern and increasing rates of key drug-resistant pathogens: 
        65 percent of surveyed physicians indicated increased rate of infections
        caused by extended-spectrum beta-lactamase- (ESBL) producing
        Enterobacteriaceae, and 57 percent of respondents reported increased
        rates of multi-drug-resistant (MDR) Pseudomonas aeruginosa over the past
        two years. Respondents are particularly concerned over MDR GNPs, with 79
        percent and 74 percent of surveyed physicians reporting a high level of
        concern regarding MDR P. aeruginosa and MDR Acinetobacter infections,
        respectively, for which few treatment options remain available.
    --  Anticipated prescribing of ceftolozane/tazobactam and
        ceftazidime/avibactam: Surveyed European physicians are highly receptive
        to new treatment options that will target resistant Gram-negative
        pathogens. Almost 90 percent of respondents are willing to prescribe
        Cubist's ceftolozane/tazobactam (CXA-201) and AstraZeneca/Forest's
        ceftazidime/avibactam (CAZ-AVI), while 80 percent would prescribe both
        therapies, if available. Despite key differences in spectrum of
        activity, likely prescribers do not perceive these emerging products to
        be well differentiated and do not prefer either agent for the treatment
        of GNIs due to key pathogens.

Comments from Decision Resources Group Infectious Disease Therapy Leader Mladen Tomich, Ph.D.:

    --  "As few options remain for targeting highly resistant GNPs such as MDR
        P. aeruginosa and Acinetobacter, physicians are increasingly turning to
        last resort therapies for these pathogens, including colistin, despite
        its notable toxicity. Hence, there is ample opportunity in the EU5
        hospital market for novel agents that are efficacious against resistant
        and MDR GNPs and have a more favorable safety profile."
    --  "While signaling a pressing need for novel antibiotics for GNIs,
        physicians are concerned about future resistance development to both
        current and emerging therapies. Our findings indicate that a narrower
        activity spectrum that includes efficacy against key resistant and MDR
        pathogens may be an important driver of hospital uptake of antibiotics,
        as physicians look to de-escalate broad-spectrum empiric therapy
        following pathogen confirmation in order to minimize resistance

About Decision Resources Group
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Decision Resources Group
Christopher Comfort

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SOURCE Decision Resources Group