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Xeljanz's Label Extension to Include Reduction of Radiographic Progression of Structural Joint Damage in RA Has Positively Impacted U.S. Rheumatologists' Perceptions of This Agent

Companies mentioned in this article: Decision Resources Group

BURLINGTON, Mass., Aug. 18, 2014 /PRNewswire/ -- Decision Resources Group finds that the FDA approval of Pfizer's supplemental New Drug Application for Xeljanz in February 2014 to include the reduction of radiographic progression of structural joint damage has had a positive impact on U.S. rheumatologists' perceptions of this rheumatoid arthritis (RA) treatment. Over three-quarters of surveyed rheumatologists indicate moderate to substantial impact by Xeljanz's labeling extension to include the inhibition of structural damage. Furthermore, nearly 80 percent of surveyed physicians believe Xeljanz is superior to methotrexate with regard to its ability to inhibit structural progression in patients with RA.

Other key findings from the report entitled LaunchTrends: Xeljanz (Wave 5):

    --  Awareness/familiarity: At 18 months post launch of Xeljanz, all surveyed
        rheumatologists report awareness of the treatment and virtually all (99
        percent) have moderate to high familiarity with the drug. Furthermore,
        rheumatologists in Wave 5 rated their familiarity with Xeljanz
        significantly higher than in all four previous waves.
    --  Xeljanz trial: Eighteen months after the launch of Xeljanz, the majority
        of surveyed rheumatologists (92 percent) in Wave 5 are users.
        Prescribers of Xeljanz in the current wave have already initiated the
        product in an average of 13 patients. The majority of Xeljanz
        prescribers (93 percent) rated the product with moderate to high
    --  Perceived advantages: The main perceived advantage of Xeljanz, unaided,
        across all five waves is its oral administration. Nearly 80 percent of
        surveyed rheumatologists in Wave 5 indicated Xeljanz's greatest
        advantage is that it is administered orally. Between one-fifth to over
        one quarter of rheumatologists across all four waves cited Xeljanz's
        unique mechanism of action as a JAK inhibitor as a main advantage of the
    --  Perceived disadvantages: Cost/insurance coverage is considered the
        greatest disadvantage of Xeljanz by approximately one-third of
        rheumatologists in Wave 5, more than in any previous wave of research.
        Safety/side effects are considered the second greatest disadvantage of
        Xeljanz by just under one-fifth of the surveyed rheumatologists in Wave

Comments from Decision Resources Group Director Lynn Price:

    --  "Nearly all of the Wave 5 surveyed rheumatologist have a moderate to
        highly favorable reaction to Xeljanz's product profile. The mean
        favorability reaction is significantly higher than in all previous
        waves, indicating that rheumatologists are increasingly improving their
        reaction, potentially because they have become familiar and aware of the
        profile's contents."
    --  "Over the past 18 months of tracking Pfizer's Xeljanz launch we have
        seen significant increases in the Xeljanz user- and patient-base, as
        well as physician-rated familiarity, initial reaction, interest and
        satisfaction with the product.  It appears that at 18 months
        post-launch, surveyed rheumatologists have become quite comfortable with
        prescribing the RA treatment and the small molecule appears to be
        finding its place in the RA treatment algorithm."

About Decision Resources Group
Decision Resources Group offers best-in-class, high-value information and insights on critical issues within the healthcare industry. Clients rely on this analysis and data to make informed decisions. Find out more at

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For more information, contact:

Decision Resources Group
Christopher Comfort

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SOURCE Decision Resources Group